Archive for February, 2009

Still Soda Free

February 25th, 2009

Readers:

Well, I’m still off of the diet soda. I haven’t had a soda
since the 15th and I’m feeling good.

It seems to be much easier than I expected, but it is still
early yet. I was soda free for months, but somehow I fell
back in the pattern of making diet sodas my drink of
choice. Hopefully, I won’t make the same mistakes as last
time.

I really do feel better. I have more energy and
I don’t feel so bloated from all of that carbonation.

I’m proud of myself and I hope that you’ll keep your
fingers crossed in the hopes that I can keep going strong.

Regards,
Steve

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Drug Combo Cuts Kidney Problems in Diabetics

NEW YORK (Reuters Health) – Treatment with the blood
pressure drugs perindopril and indapamide can help
prevent kidney problems in patients with type 2 diabetes,
according to a report in the Journal of the American
Society of Nephrology. In fact, these drugs work even
for patients who already have pressures at or below
recommended values.

Lead author Dr. Vlado Perkovic, from the University of
Sydney, Australia, and colleagues note that current
guidelines recommend that drugs be given to diabetics
to keep blood pressures below 130/80 mmHg. If kidney
disease is already present, then they should aim for
a pressure below 125/75 mmHg.

Whether aiming for even lower pressures might protect the
kidneys further has been unclear.

The ADVANCE study featured 11,140 patients with type 2
diabetes who were randomly assigned to receive perindopril-
indapamide or an inactive “placebo” pill, regardless of
their initial blood pressure.

Over an average follow-up period of 4.3 years, treatment
with the drug combo reduced kidney filtering problems,
such as protein leakage into the urine, by 21 percent,
the investigators report. As noted, the benefits were
evident regardless of starting blood pressure.

With each drop in systolic blood pressure (the upper
number on a standard reading), the risk of kidney problems
also dropped. This was apparent even with a pressure below
110 mmHg.

Still, whether the effects on kidney filtering problems
translate into more long-term clinical benefits is unknown.
“Most of the findings related to early manifestations of
kidney disease and the study was not large enough to
assess the impact of the intervention directly on the risk
of kidney failure,” Perkovic said in a statement.

SOURCE: Journal of the American Society of Nephrology,
April 2009.

Copyright Reuters Limited. All rights reserved.

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Scientists search for new diabetes therapy

OXFORD, England – British medical scientists say they are
searching for a new class of drugs to treat type 2 diabetes.

The University of Oxford researchers, funded by Britain’s
Biotechnology and Biological Sciences Research Council,
say they are using a new technology to create a cheap and
efficient method of drug discovery that will allow small
academic labs to search a large database of drugs to find
treatments for diabetes and many other diseases.

They have used the new method to identify a small molecule
that they are using to understand how insulin is secreted
in response to increases in blood sugar.

“A lot of diseases are caused by problems with important
proteins within cells,” said Grant Churchill, who is
leading the research. “We need to find small molecules
that change the function of these proteins both to discover
how they work and in addition because these small molecules
may also work as treatments for disease. The approach we
have developed allows us to do this much more quickly and
cheaply than many of the current methods. Ultimately this
will speed up the process of getting better treatments into
the clinic for patients.”

The research is reported in the journal Nature Chemical
Biology.

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Diabetic Recipe

Nacho Popcorn

(makes 12 servings)

4 quarts (4 l) air-popped corn

refrigerated butter-flavored cooking spray

2 teaspoons ground cumin

2 teaspoons garlic powder

2 teaspoons onion powder

2 teaspoons Worcestershire sauce

1/4 teaspoon Tabasco (optional)

1. Preheat oven to 300°F. Spread popped corn in a large
baking pan. Lightly coat with cooking spray. Toss and
coat again.

2. Combine cumin, garlic powder, and onion powder.
Sprinkle over popcorn. Toss to coat evenly. Drizzle
with Worcestershire sauce and Tabasco (if using).
Toss again.

3. Bake for 10 minutes, tossing once. Wrap tightly in a
pouch made from a double sheet of heavy-duty aluminum
foil.

Per serving: 45 calories (10% calories from fat),
2g protein, 1g total fat (0 saturated fat),
9g carbohydrate, 2g dietary fiber,
0 cholesterol, 11 mg sodium

Diabetic exchanges: 1/2 carbohydrate (bread/starch)

Copyright 1997-2001 Diabetic-Lifestyle.

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